Key result
Aspirin cuts coronary atherosclerotic involvement ~64% vs. atherogenic diet alone in monkeys.
Why the study?
The effect of aspirin in the primary prevention of diet-induced coronary atherosclerosis in a primate model was studied to understand its protective potential.
Does not support aspirin for primary prevention of coronary atherosclerosis; leaves open translation of primate findings to humans.
The effect of aspirin in the primary prevention of diet-induced atherogenesis in cynomolgus monkeys was studied. The diet consisted of 2% cholesterol and 10% butter by weight for 24 wk. Six monkeys received only the atherogenic diet and five monkeys received the diet plus aspirin, 81 mg/monkey per day. Aspirin did not affect plasma cholesterol levels or aortic atherosclerosis. Platelet aggregation to arachidonic acid was almost completely suppressed. Aspirin decreased significantly the number of coronary vessels with atherosclerotic involvement, and the number of coronary vessels narrowed by 20% or more. Thus, aspirin appears to exert a protective effect in the primary prevention of diet-induced coronary atherosclerosis in a primate model.
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Pick et al. (1979) studied Diet-induced coronary atherosclerosis (n=11). Aspirin vs. Atherogenic diet alone was evaluated on Percentage of coronary vessels with atherosclerotic involvement (p=<0.005). Aspirin significantly reduced the percentage of coronary vessels with atherosclerotic involvement to 4.9% compared to 13.8% with an atherogenic diet alone in cynomolgus monkeys.
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