Key result
Warfarin links to lower platelet reactivity, which discriminates bleeding from thromboembolic events.
Why the study?
Monitoring of warfarin therapy using INR does not correlate with platelet reactivity, which varies individually and may affect bleeding or thromboembolic risk.
Comparison
Platelet reactivity and coagulation status in warfarin patients versus controls
Design
Observational study measuring platelet reactivity and coagulation in vitro
Follow-up
3 months
Authors
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May identify warfarin patients at bleeding/thrombosis risk; hypothesis-generating and should not yet change practice.
Observational (n=242)
Kovács et al. (1993) conducted an observational in Patients on warfarin (n=242). Warfarin vs. Healthy controls was evaluated on Platelet reactivity to shear stress and collagen and dynamic overall coagulation. Warfarin significantly inhibited platelet reactivity compared to controls, and platelet reactivity discriminated between patients with bleeding or thromboembolic episodes during a 3-month follow-up.
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