Differential expression of microRNA in the lungs of rats with pulmonary arterial hypertension

Figures

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  Figure 1.. Differential expression of miRNAs between PAH mice and controls. (A) Hierarchical clustering of the differential expression of miRNAs between PAH and control mice. For each miRNA, green represents underexpressed and red overexpressed values compared with the average value (median), in black. Dendrograms (tree graphs) between miRNAs are depicted, where the closest branches of the tree represent miRNAs with the most similar expression pattern. (B) A total 17 miRNAs exhibited significantly difference fold changes (log 2) in expression of PAH mice when compared with controls (**P<0.01). Differential levels are normalized to all assessed miRNAs and relative to control mice. Bars represent the standard error of the mean. miR, microRNA; PAH, pulmonary arterial hypertension.

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  Figure 2.. The GO analysis of the differentially expressed miRNAs in lungs from PAH and control rats. The solid bars are the GOs targeted by downregulated miRNA. The vertical axis is the GO category and the horizontal axis is the enrichment of GO. GO, gene ontology; miRNAs, microRNAs; PAH, pulmonary arterial hypertension; ARF, ADP-ribosylation factor.

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  Figure 3.. miRNA gene network. Red boxes represent upregulated miRNA and blue boxes downregulated miRNA. Edges represent the inhibitive effect of miRNA on mRNA. miRNAs, microRNAs.

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  Figure 4.. Signaling pathway analysis regulated by miRNA-targeted genes. The vertical axis is the pathway category, and the horizontal axis is the enrichment of pathways. miRNAs, microRNAs; MAPK, mitogen-activated protein kinase; TGF-β, transforming growth factor β, Jak, Janus kinase; STAT, signal transducer and activator of transcription; GnRH, gonadotropin-releasing hormone.