Key result
Lithium-clozapine combination therapy triggers complete AV block in a patient with multiple sclerosis.
Why the study?
Complete atrioventricular block can be a lethal complication with varied causes including lithium-clozapine therapy and relapsing multiple sclerosis, which require direct treatment.
Case Report (n=1)
No
May cause CAVB in lithium-clozapine users; leaves open need for monitoring studies.
A complete atrioventricular block (CAVB) can be a lethal complication when it is not treated directly with isoprenaline and pacemaker therapy. The overall incidence of CAVB varies between 4 to 8 per cent with a mortality OR of 3.2 within 30 days if untreated. Main causes of CAVB are inferior myocardial infarction, congenital AV node malformation, mitral valve insufficiency and valve surgery, metabolic disorders and intoxications. The authors describe a case with a CAVB due to lithium-clozapine therapy and relapsing multiple sclerosis.
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Gabeler et al. (2011) conducted a case report in Complete atrioventricular block (CAVB) (n=1). Lithium-clozapine therapy was evaluated. Lithium-clozapine therapy in a bipolar patient with relapsing multiple sclerosis was identified as the cause of a complete atrioventricular block.
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