Generalized Arterial Calcification of Infancy

In some 40 reported cases of arterial calcification of infancy the proved occurrence in siblings has been described once (Menten and Fetterman, 1948).We report a further example of siblings affected by this disease.It has been described in children of either sex from the age of 1 day to 27 months, usually in the first six months of life.The clinical history and post-mortem appearances in most of the reported examples in early infancy are very similar.The children are born to apparently healthy young parents.The pregnancy and birth are normal, and there is no evidence of abnormal consumption by mother or child of poisons or poisonous dosages of calcifying substances.