Key result
CineECG detects abnormal depolarization trajectories in ~51% of preclinical PKP2 carriers with normal ECGs.
Why the study?
Visualization of abnormal ventricular activation in complex conduction disorders is challenging and requires novel imaging techniques for better insight.
Cohort (n=104)
No
May facilitate earlier detection of conduction abnormalities in plakophilin-2 carriers; leaves open clinical utility pending validation studies.
We present the use of CineECG in visualizing abnormal ventricular activation in a case of a complex conduction disorder. CineECG combines the standard 12‑lead surface ECG with a 3D anatomical model of the heart. It projects the location and direction of the average ventricular activation and recovery on the heart model over time. In this case, CineECG was able to visualize the different type of fascicular conduction in this progressive conduction block. This novel imaging technique was able to provide additional insight in this complex case, and might be of use in other complex ECG patterns.
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Schaaf et al. (2023) conducted a cohort in Preclinical Arrhythmogenic Cardiomyopathy (n=104). Preclinical plakophilin-2 (PKP2) variant carrier status vs. Age- and sex-matched control subjects with structurally normal hearts was evaluated on Abnormal CineECG depolarization trajectory. CineECG non-invasively identified abnormal depolarization trajectories in 51.4% and abnormal repolarization trajectories in 24.3% of preclinical plakophilin-2 variant carriers who had clinically normal standard 12-lead ECGs.
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