Key result
CMR MPRI measurements show notable observer variability that may alter diagnostic classification.
Why the study?
Variations in measurement of myocardial perfusion reserve index during adenosine stress CMR may affect diagnosis and risk stratification in ischemic heart disease.
Observer variability in MPRI may affect diagnostic classification; leaves open standardization of first-pass perfusion CMR quantification.
In the work recently published in Cardiovascular Diagnosis and Therapy, Goykhman et al. (1) evaluated the inter- and intra-observer variability of myocardial perfusion reserve indexes (MPRI) during first-pass perfusion cardiovascular magnetic resonance (CMR). Studies were conducted on 20 adenosine stress studies of 10 female patients with stable angina and 10 healthy volunteers. Data analysis was performed using a commercially available software tool. The authors found that variations are present in measurement of MPRI observed in post processing of perfusion data. This may affect the diagnosis of inducible perfusion abnormalities and therefore the diagnostic classification and risk stratification of patients with suspected or known ischemic heart disease.
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Korosoglou et al. (2013) conducted an editorial in Stable angina (n=20). Myocardial perfusion reserve index (MPRI) measurement was evaluated on Inter- and intra-observer variability of MPRI. Measurement of myocardial perfusion reserve indexes (MPRI) during first-pass perfusion CMR showed inter- and intra-observer variations that may affect diagnostic classification.
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