Modulatory mechanisms of cannabinoids as a window of hope to patients with sleep-related cardiometabolic risk

Intersected pathways between circadian timing system (CTS), sleep regulatory centers (SLEEP=Backspace) and endocannabinoid system (CB) towards cardiometabolic dysfunctions and disorders (cardiometabolic risk). The stress role is affected, both by peripheral (oxidative signaling and proinflammatory activation) and central (autonomic reaction) factors that are eventually related with distinct mediators as cyclooxigenase, nitric oxide and orexin, between others.