Key result
Multidisciplinary evaluation for severe primary MR linked to lower 2-year mortality vs standard care.
Why the study?
The incidence and potential impact on outcomes of missed multidisciplinary evaluation in patients with severe primary mitral regurgitation remain unknown.
Does multidisciplinary evaluation improve survival and reduce heart failure readmissions in patients with severe primary mitral regurgitation?
Cohort (n=126)
No
Does multidisciplinary evaluation improve survival and reduce heart failure readmissions in patients with severe primary mitral regurgitation?
Absolute Event Rate: 16% vs 35%
p-value: p=.06
Underreferral to multidisciplinary heart teams is common for severe primary mitral regurgitation, but evaluation is associated with increased surgical intervention rates and potentially improved mid-term survival.
Supports multidisciplinary evaluation in severe primary mitral regurgitation; leaves open causal survival benefit pending prospective trials.
Background Severe primary mitral regurgitation (MR) warrants multidisciplinary evaluation involving cardiac surgeons and structural interventional cardiologists. The incidence and potential impact on outcomes of missed evaluation remain unknown. Methods We conducted a retrospective cohort study of patients with new diagnoses of severe primary MR from an echocardiography database within a large health care network. Of 37,749 unique patients with echocardiograms, 126 had severe primary MR. We compared the 2-year survival of patients who did and did not undergo multidisciplinary evaluation. Propensity score matching was performed on the basis of The Society of Thoracic Surgeons Predicted Risk of Mortality for mitral repair. Results Of 126 patients with severe primary MR (median age, 79 years [interquartile range, 68-89 years]; 60% women), 37 (29%) underwent multidisciplinary evaluation. Evaluated patients were younger (71 [58-79] years vs 84 [73-90] years), and of those, 26 (70%) underwent operations within 37 days of evaluation. The Society of Thoracic Surgeons Predicted Risk of Mortality median was 1% (1%-5%) and 4% (1%-10%) for evaluated and unevaluated patients, respectively. Of the 74 patients matched, the mortality rate was lower in evaluated patients at 90 days (11% [n = 4] vs 27% [n = 10]; P = .08) and 2 years (16% [n = 6] vs 35% [n = 13]; P = .06). Conclusions The multidisciplinary referral rate for newly identified severe primary MR was low at 29%, with underreferral of low-risk, potentially operative candidates. The observed improved survival with multidisciplinary evaluation calls for efforts to maximize referral of this group of patients.
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Waldron et al. (2023) conducted a cohort in Severe primary mitral regurgitation (n=126). Multidisciplinary evaluation vs. No multidisciplinary evaluation was evaluated on 2-year all-cause mortality (propensity score matched) (p=.06). Multidisciplinary evaluation for newly identified severe primary mitral regurgitation was associated with lower 2-year mortality (16% vs 35%, P=0.06) compared to no multidisciplinary evaluation.
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