Key result
Higher NIHSS, glucose, and delayed reperfusion are linked to worse 3-month mechanical thrombectomy outcomes.
Why the study?
Risk factors associated with clinical outcomes after mechanical thrombectomy in acute ischemic stroke patients were not comprehensively analyzed.
Cohort (n=212)
p-value: p=<0.05
These associations may aid post-thrombectomy risk stratification; leaves open whether targeting modifiable factors improves outcomes.
BACKGROUND: Mounting evidence has shown that mechanical thrombectomy (MT) improves clinical outcomes for large vessel occlusions (LVOs) in patients with acute ischemic stroke (AIS) of the anterior circulation. The present study aimed to provide a comprehensive analysis of risk factors associated with clinical outcomes in AIS patients receiving MT. METHODS: A total of 212 consecutive patients who underwent MT for AIS were enrolled in the present study. Clinical characteristics were recorded at admission. Two endpoints were defined according to the 3-month modified Rankin scale (mRS) score after AIS (good outcome, mRS 0-2; and death, mRS 6). Additionally, we compared the clinical outcomes and safety of MT alone and bridging therapy in AIS patients. RESULTS: Of the 212 patients treated with MT, 114 (53.77%) patients had a good outcome and 31 (14.62%) died. The incidence of a worse outcome after MT was significantly elevated in males and patients with high WBC counts, high admission blood glucose levels, high baseline NIHSS scores and a long interval time from groin puncture to reperfusion in AIS patients treated with MT after adjustment for covariates (P<0.05); these risk factors were further confirmed by our constructed nomograms. In addition, we observed no significant benefit of bridging therapy compared to MT alone in AIS patients. CONCLUSION: Our constructed nomogram based on male sex, admission WBC, admission blood glucose, NIHSS, and the interval time from groin puncture to reperfusion predicts prognosis after mechanical thrombectomy in patients with acute ischemic stroke.
No takes yet. Share an insight, caveat, or question.
Sun et al. (2021) conducted a cohort in Acute Ischemic Stroke (n=212). Clinical and procedural risk factors (male sex, high WBC, high blood glucose, high NIHSS, long interval to reperfusion) was evaluated on 3-month clinical outcome (good outcome [mRS 0-2] and death [mRS 6]) (p=<0.05). Male sex, high WBC, high glucose, high NIHSS, and long interval to reperfusion were significantly associated with worse 3-month outcomes after mechanical thrombectomy for acute ischemic stroke (P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: