Key result
MMP1 1G allele linked to ~93% higher risk of essential hypertension.
Why the study?
Matrix metalloproteinases gene polymorphisms contribute to the risk of developing cardiovascular diseases, but their association with essential hypertension in a Burkinabè population was unclear.
Case-Control (n=145)
Yes
Odds Ratio: 1.93 (95% CI 1.12–3.37)
Absolute Event Rate: 78% vs 64%
p-value: p=0.012
Genetic polymorphisms in the MMP1 (1G allele) and MMP3 (5A allele) genes, along with elevated HDL and blood glucose, were identified as independent risk factors for essential hypertension in a Burkinabè population.
Background: Matrix metalloproteinases (MMPs) gene polymorphisms contribute to the risk of developing cardiovascular diseases. This study aimed to determine the possible association of two polymorphisms of two MMP genes (MMP1 and MMP3) with essential hypertension (EH) in a Burkinabè population. Method: The genomic DNA of 72 hypertensive patients and 73 normotensive patients was extracted from their blood samples by the Salting Out technique. The −1607 1G/2G MMP1, −1171 5A/6A MMP3 polymorphisms were detected by the allele-specific polymerase chain reaction technique. Results: The chi-squared test shows that an association exists between frequencies of alleles 1G (OR = 1.93; p = 0.012) and 5A (OR = 1.9; p = 0.013); genotypes 1G1G (p = 0.007) and 5A5A (p = 0.0001) and EH in the study population. So, the frequencies of the combined 1G1G/5A5A and 2G2G/6A6A genotypes were higher in cases (p = 0.0068). Multinomial logistic regression found that HDL cholesterol (OR = 38.27; p = 0.011), blood glucose (OR = 2. 46; p = 0.009), family history of hypertension (OR = 6.88; p = 0.03), lack of exercise (OR = 23.85; p = 0.008), were independent risk factors for developing essential hypertension in our general study population. Conclusion: Our study suggests that genetic polymorphism in MMP1 and MMP3 might be helpful in determining susceptibility to EH in Burkinabè patients. In addition, susceptibility to EH might be related to MMP1 and MMP3 gene expression, which affect its plasma levels.
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Bado et al. (2025) conducted a case-control in Essential Hypertension (n=145). MMP1 1G allele polymorphism vs. MMP1 2G allele was evaluated on Essential hypertension associated with MMP1 1G allele frequency (OR 1.93, 95% CI 1.12-3.37, p=0.012). The presence of the MMP1 1G allele was associated with a nearly twofold increased risk of essential hypertension (OR 1.93) in a Burkinabè population.
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