The activities of the lysosomal hydrolases α-l-fucosidase, α-d-mannosidase, β-d-galactosidase, and N-acetyl-β-d-glucosa-minidase are significantly elevated in epididymal fat tissue and in serum from streptozotocin-diabetic rats compared with those from age-matched normal controls. Acid phosphatase activity is significantly raised over control values in epididymal fat tissue and, perhaps, liver from streptozotocin-diabetic rats. In contrast, rats fasted 72 hr show increased activities of all the glycosidases and acid phosphatase in their liver and serum. Glycosidase and acid phosphatase activities of epididymus, kidney, spleen and testis are not affected by streptozotocin-diabetes.
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Rosenblit et al. (1974) studied this question.