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A lactose-bearing norbornene imide template was poly- merized using (Cy3P)2Cl2Ru=CHPh to produce a lactose-substitut- ed neoglycopolymer. The resulting polymer showed a 100-fold overall increase in inhibitory potency (5-fold increase on a per sac- charide residue basis) compared to monomeric lactose in both a ga- lectin-binding assay and an Erythrina corallodendrum hemagglutination assay.
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Nicola L. B. Pohl (1999) studied this question.
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