Key result
circNFIB overexpression attenuates cardiac fibroblast proliferation by sponging miR-433.
Why the study?
The role of circular RNA circNFIB in cardiac fibrosis and its interaction with miR-433 as a potential therapeutic target was not well understood.
p-value: p=<0.05
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Hypothesis-generating for circNFIB-targeted antifibrosis in heart disease; requires in vivo validation before clinical consideration.
Zhu et al. (2019) studied Cardiac fibrosis. circNFIB overexpression vs. Empty vector or scrambled siRNA was evaluated on Cardiac fibroblast proliferation (EdU incorporation) (p=<0.05). Overexpression of circNFIB attenuated TGF-β-induced cardiac fibroblast proliferation by acting as an endogenous sponge for miR-433.
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