Key result
Pink grapefruit juice prolongs peak QTc by ~13 ms at 5 hours in healthy adults.
Why the study?
The effects of dietary flavonoids on cardiac electrophysiology, including potential antiarrhythmic and proarrhythmic consequences, have not been studied systematically.
Population
10 healthy volunteers
Comparison
Oral ingestion of 1 L grapefruit juice vs baseline
Design
Physiological study with electrophysiological measurements in humans
Follow-up
5 hours after ingestion
Authors
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Dietary flavonoids may prolong QTc via HERG block; leaves open arrhythmia risk from routine intake.
Mean Difference: 12.5
p-value: p=0.02
Zitron et al. (2005) studied Healthy volunteers (n=10). Pink grapefruit juice was evaluated on Peak QTc prolongation (12.5 ± 4.2 ms, p=0.02). Oral ingestion of 1 L of pink grapefruit juice significantly prolonged peak QTc by 12.5±4.2 ms at 5 hours in healthy volunteers (P=0.02).
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