Key result
Atrial fibrillation or flutter linked to ~3-fold higher thromboembolism risk in LAA aneurysm.
Why the study?
Congenital left atrial appendage aneurysm is an extremely rare anomaly with variable presentation and limited data on prenatal diagnosis and outcomes.
Systematic Review (n=216)
Odds Ratio: 3.1 (95% CI 1.6–7.88)
p-value: p=0.04
AF/flutter may heighten thromboembolic risk in LAA aneurysm; leaves open need for prospective data on anticoagulation.
Congenital left atrial appendage aneurysm is an extremely rare anomaly. It is seen at any time ranging from fetal to ninth decade of life. Patients with left atrial appendage aneurysm may be asymptomatic, or present with dyspnea, arrhythmias, thromboembolic phenomenon. We report a case of prenatal diagnosis at 26 weeks of gestation, postnatal management and outcome of left atrial appendage aneurysm.
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Su et al. (2021) conducted a systematic review in Left atrial appendage aneurysm (LAAA) (n=216). Atrial fibrillation or atrial flutter vs. Absence of atrial fibrillation or flutter was evaluated on Thrombus formation or thromboembolism (OR 3.1, 95% CI 1.6-7.88, p=0.04). In patients with left atrial appendage aneurysm, the presence of atrial fibrillation or flutter was significantly associated with an increased risk of clot formation and thromboembolism (OR 3.1).
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