Birlamchi poliklinika tizimida arterial gipertenziya profilaktikasining klinik va tashkiliy jihatlari

Arterial hypertension (AH) remains the leading modifiable risk factor for cardiovascular diseases. The aim of the study is to identify gender characteristics of hypertension phenotypes in the working-age population and to develop a screening algorithm for primary healthcare. The cross-sectional study included 1,798 patients with newly detected hypertension (704 men, 1094 women) from 4 clinics in the Navoi region (Uzbekistan). Analysis of clinical-anamnestic, anthropometric, laboratory data, and quality of life was conducted. A screening algorithm questionnaire with weighting coefficients has been developed. “Rejuvenation” of hypertension was identified: 30.1% of patients were aged 25-44. Men were characterized by behavioral risk factors (31.5% smoking, 36.2% alcohol consumption), while women were characterized by metabolic risk factors (42.5% obesity, 68.6% dyslipidemia, 38.8% chronic kidney disease). Depression (HADS ≥8) is associated with obesity (OR=2.22; 95% CI 1.78–2.77) and dyslipidemia. An 11-factor screening algorithm has been developed with risk thresholds: low (0–4), moderate (5–9), high (10–14), and very high (≥15). Two gender phenotypes of hypertension were identified: “behavioral” (men) and “metabolic-psycho-emotional” (women). The proposed screening algorithm is adapted for primary care conditions and requires prospective validation.