Key result
Distinct left atrial substrate and electrogram features characterize patients with AF and hypertrophic cardiomyopathy.
Why the study?
The electrophysiological characteristics of the left atrial substrate and intracardiac electrograms in HCM-related atrial fibrillation remain incompletely characterized.
What are the electrophysiological characteristics of the left atrial substrate and intracardiac electrograms in patients with atrial fibrillation and hypertrophic cardiomyopathy?
Observational
What are the electrophysiological characteristics of the left atrial substrate and intracardiac electrograms in patients with atrial fibrillation and hypertrophic cardiomyopathy?
This exploratory study characterizes the electrophysiological features of the left atrial substrate in patients with hypertrophic cardiomyopathy and atrial fibrillation.
Hypothesis-generating on LA substrate in HCM-AF; leaves open optimal rhythm-control strategies pending validation.
Atrial fibrillation (AF) is the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM) and is associated with relevant clinical consequences [1]. Although timely rhythm-control strategies are critical, the electrophysiological characteristics of the left atrial (LA) substrate and intracardiac electrograms (EGMs) in HCM-related AF remain incompletely characterized [2]. Given the limited available evidence, this study was conceived as an exploratory, hypothesis-generating analysis aimed at describing and comparing LA substrate characteristics rather than testing definitive clinical outcome associations or comparing ablation efficacy between groups.
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Mascia et al. (2026) conducted an observational in Atrial Fibrillation and Hypertrophic Cardiomyopathy. Hypertrophic cardiomyopathy was evaluated on Left atrial (LA) substrate characteristics and intracardiac electrograms (EGMs). This exploratory, hypothesis-generating analysis described left atrial substrate characteristics and intracardiac electrograms in patients with atrial fibrillation and hypertrophic cardiomyopathy.
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