Key result
Having 5 metabolic syndrome components linked to ~2.7-fold higher incident CVD risk vs. 0 components.
Why the study?
Few studies have investigated the association between dietary patterns derived from reduced rank regression and predicted 10-year cardiovascular disease risk.
Cohort (n=144,966)
No
Hazard Ratio: 2.72 (95% CI 2.38–3.12)
Absolute Event Rate: 6.9% vs 1.4%
p-value: p=<0.001
Metabolic syndrome component count was associated with higher CVD risk; leaves open whether dietary patterns modify this dose-response relationship.
The impact of diet on the metabolic syndrome (MetS) and CVD has been investigated widely, but few studies have investigated the association between dietary patterns (DP) and the predicted CVD, derived from reduced rank regression (RRR). The objectives of this study were to derive DP using RRR and principal component analysis (PCA) and investigate their associations with the MetS and estimated 10-year atherosclerotic CVD (ASCVD). We used the baseline dataset from the Xinjiang multi-ethnic cohort study in China, collected from June 2018 to May 2019. A total of 14 982 subjects aged 35-74 years from Urumqi, Huo Cheng and Mo Yu were included in the analysis. The 10-year ASCVD risk was estimated using the Chinese ASCVD risk equations. The associations of DP with the MetS and 10-year ASCVD were determined using multivariable logistic regression models. In Urumqi and Mo Yu, the increased RRR DP score was associated with a higher OR of having the MetS and with a higher OR of elevated 10-year ASCVD risk. However, only the first DP determined by PCA in Urumqi was inversely associated with the MetS and elevated 10-year ASCVD risk. The prevalence of the MetS and elevated ASCVD risk in urban population is higher than that in rural areas. Our results may help nutritionists develop more targeted dietary strategies to prevent the MetS and ASCVD in different regions in China.
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Hailili et al. (2020) conducted a cohort in Metabolic Syndrome and Cardiovascular Disease (n=144,966). 5 metabolic syndrome components vs. 0 metabolic syndrome components was evaluated on Incident cardiovascular disease (CVD) (aHR 2.72, 95% CI 2.38-3.12, p=<0.001). The presence of 5 metabolic syndrome components significantly increased the risk of incident cardiovascular disease compared to 0 components (aHR 2.72), demonstrating a strong cumulative dose-response relationship.
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