Key result
Elevated CRP-to-albumin ratio distinguishes familial hypercholesterolemia from healthy controls with ~0.72 AUC.
Why the study?
The study aimed to evaluate the CRP-to-albumin ratio and blood count parameters in patients with familial hypercholesterolemia to assess their diagnostic and monitoring value.
Does the CRP-to-albumin ratio distinguish patients with familial hypercholesterolemia from healthy controls?
Case-Control (n=136)
No
Does the CRP-to-albumin ratio distinguish patients with familial hypercholesterolemia from healthy controls?
The CRP-to-albumin ratio is significantly elevated in patients with familial hypercholesterolemia and shows potential as an inflammatory biomarker to distinguish these patients from healthy individuals.
Objectives: This study aimed to evaluate the CRP-to-albumin ratio (CAR) and complete blood count parameters in patients with familial hypercholesterolemia (FH). Methods: A retrospective study included 101 patients (61 female) and 35 healthy controls (18 female) who visited our hospital from January 2015 to June 2018. Serum levels of total cholesterol (TC), triglycerides (TG), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), albumin, and CRP were measured using the Hitachi 917 biochemistry analyzer. Complete blood count was performed with the Abbott CELL-DYN Ruby® hematology analyzer. Statistical analysis was conducted with SPSS 27. Results: The FH patients had significantly higher median values of TC (328 mg/dL), TG (218 mg/dL), LDL-C (269 mg/dL), CRP (5.6 mg/dL), WBC (8.3×10^3/uL), NEU (4.9×10^3/uL), PLT (286×10^3/uL), and CAR (0.128), compared to the healthy controls. Significant differences were found between the two groups in TC, TG, LDL-C, albumin, CRP, CAR, WBC, NEU, LYM, and PLT (p<0.05). The area under the curve (AUC) for CAR was 0.715, indicating its potential to distinguish FH patients from healthy controls (95% Confidence Interval: 0.626-0.824). Conclusion: CAR is a valuable inflammatory marker for diagnosing and monitoring familial hypercholesterolemia, showing significant differences between FH patients and healthy controls.
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Özkaya et al. (2025) conducted a case-control in Familial hypercholesterolemia (n=136). CRP-to-albumin ratio (CAR) vs. Healthy controls was evaluated on Diagnostic capability to distinguish familial hypercholesterolemia patients from healthy controls (AUC 0.715, 95% CI 0.626-0.824, p=0.0001). The CRP-to-albumin ratio was significantly elevated in patients with familial hypercholesterolemia compared to healthy controls (median 0.128 vs 0.044) and distinguished the groups with an AUC of 0.715.
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