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January 1, 2023Journal of Biosciences and MedicinesOpen Access

Assessment of C-Reactive Protein/Serum Albumin Ratio in Relation to Acute Presentation and Early Outcome of Patients with Acute Coronary Syndrome

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Key result

High C-reactive protein to albumin ratio (CAR) was identified as a significant independent predictor for in-hospital major adverse cardiac events in patients with acute coronary syndrome.

Why the study?

The C-reactive protein to albumin ratio is a newly introduced marker that may provide better prognostic utility than either marker alone, but its association with in-hospital short-term MACE in ACS required assessment.

Does the C-reactive protein to albumin ratio (CAR) predict in-hospital short-term MACEs in patients with acute coronary syndrome?

Population

132 patients diagnosed with ACS in CICUs in Baghdad

Comparison

C-reactive protein to albumin ratio at hospital admission

Design

Multicenter prospective cohort study

Authors

WTWaseem F. Al TameemiNahrain UniversityNANoor Alaa Alkhazraji

Discussion

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Member takes

Implication

CAR may aid early risk stratification in ACS; hypothesis-generating and should not yet change practice without validation.

Study Design

Type

Cohort (n=132)

Multicenter

Yes

Structured PICO

Does the C-reactive protein to albumin ratio (CAR) predict in-hospital short-term MACEs in patients with acute coronary syndrome?

P
Population
132 patients aged 30-85 years with acute coronary syndrome admitted to coronary intensive care units, followed during their hospital stay (mean 5.14 days).
E
Exposure
Assessment of C-reactive protein to albumin ratio (CAR) at hospital admission
O
Outcome
In-hospital short-term major adverse cardiac events (MACEs) including cardiogenic shock, arrhythmias, post-MI angina, and acute heart failurecomposite

Main Result

p-value: p=<0.001

The C-reactive protein to albumin ratio (CAR) at admission serves as a significant independent predictor of in-hospital adverse events in patients with acute coronary syndrome.

Limitations

  • Interfering factors with baseline measurement for serum albumin and CRP such as BMI and nutritional status
  • Need for monitoring levels of both parameters during patient recovery

Cite This Study

Tameemi et al. (2023) conducted a cohort in Acute Coronary Syndrome (ACS) (n=132). High C-reactive protein to albumin ratio (CAR) vs. Low C-reactive protein to albumin ratio (CAR) was evaluated on In-hospital short-term major adverse cardiac events (MACEs) (p=<0.001). High C-reactive protein to albumin ratio (CAR) was identified as a significant independent predictor for in-hospital major adverse cardiac events in patients with acute coronary syndrome.

synapsesocial.com/papers/6a9c0aaf7952928fedcaf514https://doi.org/10.4236/jbm.2023.112019
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein2008 · 6,733 citations
  2. 2Prognostic Efficacy of High-Sensitivity C-Reactive Protein to Albumin Ratio in Patients with Acute Coronary Syndrome2019 · 62 citations
  3. 3Predictive Value of C-Reactive Protein to Albumin Ratio in ST-Segment Elevation Myocardial Infarction Patients Treated With Primary Percutaneous Coronary Intervention2020 · 36 citations
  4. 4C-reactive protein/albumin ratio designates advanced heart failure among outpatients with heart failure2020 · 8 citations
  5. 5Usefulness of The C‐Reactive Protein/Albumin Ratio for Predicting No‐Reflow in ST ‐elevation myocardial infarction treated with primary percutaneous coronary intervention2018 · 87 citations