Key result
Baseline C-Reactive Protein to Albumin Ratio was significantly higher in patients with intermediate-high Syntax scores compared to those with low scores (P < .0001).
Why the study?
Syntax score categorization informs CAD prognosis and revascularization policy, but whether baseline CRP to albumin ratio is associated with SS in chronic coronary syndromes remains to be determined.
Is the baseline C-reactive protein to albumin ratio associated with coronary artery disease severity (Syntax score) in patients with chronic coronary syndromes?
Cross-Sectional (n=100)
null
No
Is the baseline C-reactive protein to albumin ratio associated with coronary artery disease severity (Syntax score) in patients with chronic coronary syndromes?
p-value: p=<.0001
The C-reactive protein to albumin ratio is an independent indicator of intermediate-high Syntax score in patients with chronic coronary syndromes, suggesting its utility as a simple inflammatory marker for CAD severity.
Background: Syntax score (SS), which is an angiographic technique used in categorizing the severity of coronary artery disease (CAD), has a significant prognosis in coronary artery disease (CAD) and explain an important information concerning selection of revascularization policy. C-reactive protein (CRP) and albumin are markers of inflammation, and high levels of them are associated with high SS. Aim of the Work: To detect whether baseline CRP to albumin ratio (CAR), an easily available and novel inflammatory indicator, is associated with SS in patients with chronic coronary syndromes. Methodology: This study was carried out on 100 patients having chronic coronary syndromes for whom, a diagnostic coronary angiography was done at Sohag University Cath. Lab unit in the period from January -July 2021. Patients were divided randomly into two equal groups:*Group I, patients having low SS (≤22). *Group II, patients having intermediate-high SS (>22).Results: C-Reactive Protein/Albumin Ratio was significantly higher in patients having intermediate-high SS group (P < .0001). In multivariate regression analysis, CAR was an independent indicator of intermediate-high SS group together with LDL. Conclusion: CAR was more intensely related to the severity of CAD than CRP and albumin alone and was detected to be an independent indicator for intermediate- high SS group.
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Ghaleb et al. (2021) conducted a cross-sectional in Chronic coronary syndromes (n=100). C-Reactive Protein to Albumin Ratio (CAR) vs. Low Syntax score (≤22) was evaluated on Intermediate-high Syntax score (>22) (p=<.0001). Baseline C-Reactive Protein to Albumin Ratio was significantly higher in patients with intermediate-high Syntax scores compared to those with low scores (P < .0001).
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