Key result
C-reactive protein to albumin ratio (CAR) was positively correlated with coronary artery calcium score (r=0.384, p<0.001) and CAD-RADS score (r=0.462, p<0.001) in patients undergoing coronary CTA.
Why the study?
The C-reactive protein to albumin ratio is a predictive marker of systemic inflammation in atherosclerotic coronary diseases, but its relationship with coronary artery calcium and CAD-RADS scores required evaluation.
Is the C-reactive protein to albumin ratio (CAR) associated with coronary artery calcium (CAC) score and CAD-RADS score in patients undergoing coronary CTA for chest pain?
Observational (n=187)
Is the C-reactive protein to albumin ratio (CAR) associated with coronary artery calcium (CAC) score and CAD-RADS score in patients undergoing coronary CTA for chest pain?
Effect estimate: r= 0.384 (CAC) and r= 0.462 (CAD-RADS)
p-value: p=< 0.001
Higher C-reactive protein to albumin ratio is independently associated with higher coronary artery calcium and CAD-RADS scores, suggesting its potential as a predictive marker for atherosclerosis.
CAR may correlate with CAC and CAD-RADS on CTA; leaves open incremental prognostic value in suspected CAD.
BACKGROUND: : C-reactive protein (CRP) to albumin ratio (CAR) is predictive marker of systemic inflammatory state in atherosclerotic coronary diseases when compared to predictive value of these two markers separately. We aimed to evaluate the relationship between CAR and the coronary artery calcium (CAC) score, Coronary Artery Disease-Reporting and Data System (CAD-RADS) score in patients' unknown diagnosis of coronary artery disease (CAD) underwent coronary CTA (Computed Tomography Angiography) and were classified by CAD-RADS scores. METHODS: A total of 187 patients consecutively referred for the evaluation of their chest pain underwent coronary CTA were included retrospectively. RESULTS: CRP, CAR, and CAD-RADS scores were higher in patients with CAC score > 400 than the other groups (p < 0.001). We found positive correlation between CAR and CAC score (r= 0.384, p < 0.001), and also there was a positive correlation between CAR and CAD-RADS score (r= 0.462, p < 0.001). Multivariate logistic regression analyses showed that low density lipoprotein cholesterol (LDL-C), CAD-RADS score, and CAR were independent predictors of CAC score (p < 0.05). DISCUSSION: Higher CAR can be a predictive marker of atherosclerosis and CAD. CAR may be useful in the management of patients before invasive coronary angiography. Further studies are needed to clarify the pathophysiologic role of CAR in patients with atherosclerotic coronary heart diease.
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Erdöl et al. (2021) conducted an observational in Unknown diagnosis of coronary artery disease (CAD) with chest pain (n=187). C-reactive protein to albumin ratio (CAR) was evaluated on Coronary artery calcium (CAC) score and CAD-RADS score (r= 0.384 (CAC) and r= 0.462 (CAD-RADS), p=< 0.001). C-reactive protein to albumin ratio (CAR) was positively correlated with coronary artery calcium score (r=0.384, p<0.001) and CAD-RADS score (r=0.462, p<0.001) in patients undergoing coronary CTA.
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