Key result
A higher C-reactive protein-to-albumin ratio was an independent determinant of slow coronary flow in patients with stable angina pectoris (OR 1.023; 95% CI 1.013-1.034; P<0.001).
Why the study?
Data were lacking regarding the role of C-reactive protein-to-albumin ratio in slow coronary flow among patients with stable angina pectoris.
Is the C-reactive protein-to-albumin ratio (CAR) associated with the presence of slow coronary flow in patients with stable angina pectoris?
Observational (n=217)
Is the C-reactive protein-to-albumin ratio (CAR) associated with the presence of slow coronary flow in patients with stable angina pectoris?
Odds Ratio: 1.023 (95% CI 1.013–1.034)
p-value: p=<0.001
Higher C-reactive protein-to-albumin ratio is independently associated with the presence of slow coronary flow in patients with stable angina pectoris.
CAR was associated with slow coronary flow; hypothesis-generating and should not yet alter management in stable angina.
BACKGROUND: The relationship between severity of coronary artery disease and inflammatory parameters has been previously demonstrated. However, there is a lack of data regarding the role of C-reactive protein-to-albumin ratio (CAR) in slow coronary flow (SCF) in patients with stable angina pectoris (SAP). In this study, we aimed to investigate the relationship between CAR and presence of SCF in patients with SAP. PATIENTS AND METHODS: This study enrolled 217 patients undergoing coronary angiography for SAP. SCF was detected in 81 (37.3%) patients, and the control group included 136 patients. All clinical, demographical, and laboratory parameters were entered into a dataset and compared between SCF group and the controls. RESULTS: The mean age of the patients was 66.1 ± 12.1 years (male: 57.1%). C-reactive protein and CAR were significantly higher in patients with SCF compared with controls (P = 0.004 and < 0.001, respectively). Logistic regression analysis demonstrated that high CAR level was an independent determinant of SCF (odds ratio: 1.023; 95% confidence interval: 1.013-1.034; P < 0.001). CONCLUSION: Higher CAR level may be a valuable predictor of SCF in patients with SAP who undergo coronary angiography. Inflammation may play an important role in the pathogenesis of SCF.
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Yesın et al. (2019) conducted an observational in Stable angina pectoris (n=217). C-reactive protein-to-albumin ratio (CAR) vs. Lower CAR level was evaluated on Slow coronary flow (SCF) (OR 1.023, 95% CI 1.013-1.034, p=<0.001). A higher C-reactive protein-to-albumin ratio was an independent determinant of slow coronary flow in patients with stable angina pectoris (OR 1.023; 95% CI 1.013-1.034; P<0.001).
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