Key result
Severe hypertension links to poor BP control in over half of patients despite multiple medications.
Why the study?
The characteristics and blood pressure control of patients with severe uncontrolled hypertension in a Jamaican specialist private practice were not well described.
Observational (n=48)
No
Severe hypertension often evades control despite four or more agents in specialist care; leaves open optimal multidrug regimens for similar Caribbean cohorts.
OBJECTIVE: To determine the characteristics of patients with severe uncontrolled hypertension, in a Jamaican specialist practice; the level of blood pressure control achieved in routine clinical practice, and the number/type of antihypertensive medications required for blood pressure control. DESIGN: This was a retrospective analysis of the medical records of 500 consecutive patients presenting to a consultant physician private group-practice between January and December 2000. Data were extracted from the records of the 48 patients with severe (Grade III) hypertension (WHO/ISH). RESULTS: Fifty per cent (252) werefound to be hypertensive, 19% (48) had Grade III hypertension. The patients with severe uncontrolled hypertension were of mixed ethnicity, predominantly African. Most were less than 65 years old, never smoked cigarettes and were overweight/obese. Nearly one-half had LDL cholesterol >3.4 mg/dL. Diabetes (31%) and congestive heart failure (21%) were the most common comorbid conditions. Fifteen per cent had no illnesses other than severe hypertension. Cardiovascular symptoms were predominant, followed by dizziness. Only 19% of patients were asymptomatic. More than half of the patients achieved blood pressure > 140/90 mm Hg during the study period. Most patients received four drugs and the number of drugs prescribed increased with duration of follow-up. The antihypertensive medications most prescribed at one year were--angiotensin converting enzyme inhibitors (87%), diuretics (78%), calcium channel blockers (63%) and beta-blockers (69%). CONCLUSION: Severe hypertension was a common problem in the specialist private practice in Jamaica. Most patients had cardiovascular symptoms, were dyslipidaemic and required four or more antihypertensive drugs for adequate long-term control.
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Lalljie et al. (2005) conducted an observational in Severe (Grade III) hypertension (n=48). Severe uncontrolled hypertension was evaluated on Patient characteristics, blood pressure control levels, and required antihypertensive medications.
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