Answers are grounded in this paper and cite their sources.
Pinning down the role of the anchor: The chemical synthesis of a cysteine-modified glycosylphosphatidylinositol (GPI) anchor provides access to homogeneous GPI-anchored prion protein through expressed protein ligation (see scheme). By this method, it should be possible to investigate the influence of the complex posttranslational GPI modification on protein structure and function.
No takes yet. Share an insight, caveat, or question.
Becker et al. (2008) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: