Key result
Congenital infections are linked to diverse cardiovascular sequelae, including structural defects and cardiomyopathies.
Why the study?
Cardiovascular abnormalities caused by congenital or perinatal infections leading to cardiomyocyte injury and inflammation require comprehensive review of associated cardiovascular sequelae.
Congenital and perinatal infections are associated with diverse and significant cardiovascular sequelae, emphasizing the need for awareness, prevention, and timely diagnosis.
May inform pediatric CV risk recognition from congenital infections; leaves open need for prospective prevention studies.
Background Cardiovascular abnormalities may be caused by congenital or perinatal infections that cause cardiomyocyte injury and inflammation. Aim of review The purpose of this article is to review common congenital infections associated with cardiovascular sequelae , including pathogenesis, cardiovascular manifestations, diagnosis, treatment, prevention, and public health implications. Key scientific concepts of review Congenital rubella syndrome occurs from transplacental transmission of rubella virus and may cause patent ductus arteriosus , pulmonary valvular or pulmonary artery stenosis , or ventricular septal defect . Congenital HIV occurs from HIV transmission during pregnancy, delivery, or breastfeeding and may cause dilated cardiomyopathy , left ventricular dilation, thickening of the interventricular septum and posterior wall, or myocarditis . Enterovirus infection occurs from fecal-oral contact or respiratory transmission of enteroviruses such as coxsackievirus and may cause myocarditis and structural heart defects, especially ventricular septal defect . Zika virus infection occurs from mosquito bites, sexual contact, or transplacental transmission and may cause left ventricular hypertrophy , nondipping blood pressure, diastolic dysfunction , and valvular regurgitation. Other congenital viral infections that may cause cardiovascular disease include cytomegalovirus , parvovirus B19 , and SARS-CoV-2. Congenital syphilis occurs from transmission of Treponema pallidum during pregnancy or delivery and may cause aortitis , aortic aneurysm , and aortic regurgitation . Chagas disease occurs from Trypanosoma cruzi transmission through the feces of infected triatomine bugs, transplacental transmission, blood transfusions , and organ transplants and may cause arrhythmias , left ventricular wall motion abnormalities, complete heart block , ventricular dysfunction , and heart failure. Prevention of congenital infections may include vaccination , prenatal and perinatal screening, and other public health measures.
No takes yet. Share an insight, caveat, or question.
Arriola-Montenegro et al. (2024) conducted a review in Congenital infections with cardiovascular sequelae. Congenital infections was evaluated. Congenital infections such as rubella, HIV, enterovirus, Zika, syphilis, and Chagas disease are associated with various cardiovascular sequelae including structural defects and cardiomyopathies.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: