Key result
Y-chromosome HindIII+ allele linked to higher hypertension risk in early MI, appearing in ~46% vs 26%.
Why the study?
The influence of Y chromosome loci on the risk of cardiovascular diseases, including coronary artery disease, in men was unclear.
Case-Control (n=386)
Y chromosome SNP was associated with blood pressure; leaves open its role in early MI risk pending replication.
A single nucleotide polymorphism (SNP) in chromosome Y has been associated with blood pressure. In men, the risk of suffering from cardiovascular diseases, including coronary artery disease, could be influenced by one or more loci on chromosome Y. We genotyped 208 men who had suffered an early episode of myocardial infarction (MI) (< or =55 years) and 178 healthy control men for two Y-polymorphisms (a HindIII polymorphism in an alphoid satellite in the centromeric non-recombining region and the -2627 T/C in the SRY gene). Frequencies were compared through a chi(2)-test. Frequencies for the two polymorphisms did not differ between patients and controls. The alphoid-HindIII polymorphism was not related to blood pressures in our population (HindIII+: diastolic, 80 +/- 2; systolic, 129 +/- 5. HindIII-: diastolic, 80 +/- 2; systolic, 128 +/- 3). Seventy-six patients (37%) were hypertensives and had a significantly higher frequency of the HindIII+ allele compared to the normotensive patients (46 and 26%, respectively; P = 0.028). According to our data, the alphoid-HindIII polymorphism in chromosome Y was not associated with differences in blood pressure in men from Asturias (Northern Spain). However, the HindIII+ allele increased the risk of suffering an early episode of MI among hypertensives.
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García et al. (2003) conducted a case-control in Myocardial infarction and hypertension (n=386). Y-chromosome alphoid-HindIII polymorphism vs. Normotensive patients / Healthy controls was evaluated on Frequency of the HindIII+ allele among hypertensive versus normotensive MI patients (p=0.028). The HindIII+ allele on the Y chromosome occurred more frequently in hypertensive men with early myocardial infarction compared to normotensive patients (46% vs 26%, P=0.028).
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