Key result
Adolescent type 1 diabetes is linked to ~4-point lower endothelium-dependent dilatation vs. controls.
Why the study?
The role of macroangiopathy in young people with insulin-dependent diabetes mellitus (IDDM) and its relationship to endothelial and smooth muscle function was unclear.
Case-Control (n=40)
Absolute Event Rate: 5% vs 9%
p-value: p=0.0002
Suggests early vascular dysfunction in adolescents with type 1 diabetes; leaves open its prognostic value and need for intervention trials.
Using a novel ultrasound method, brachial artery endothelial and smooth muscle physiology were studied in 20 adolescents with IDDM and in 20 nondiabetic subjects matched for age (13-22 years), gender and vessel size. Endothelium-dependent dilatation (EDD) was assessed in response to flow (EDD) and endothelium-independent vasodilatation after sublingual glyceryl trinitrate (GTN). Both EDD and GTN were reduced in those with IDDM compared with controls: 5 vs. 9%, (p = 0.0002) and 14 vs. 21% (p = 0.002). Abnormal EDD was found in 12 IDDM adolescents (diabetes duration 3.3-14.9 years). The mean urinary albumin excretion rate of the diabetic group with abnormal EDD was 5.76 +/- 2.82 vs. 8.05 +/- 4.88 microg/min in those with normal EDD (p = 0.25). In the diabetic adolescents there was no significant correlation observed between the test for early large vessel disease, HbAlc and tests for diabetic microangiopathy.
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Donaghue et al. (1998) conducted a case-control in Insulin-dependent diabetes mellitus (IDDM) (n=40). Insulin-dependent diabetes mellitus (IDDM) vs. Nondiabetic matched controls was evaluated on Endothelium-dependent dilatation (EDD) in response to flow (p=0.0002). Adolescents with IDDM had significantly reduced endothelium-dependent dilatation (5% vs 9%, p=0.0002) and endothelium-independent vasodilatation compared to matched nondiabetic controls.
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