Key result
Class III obesity links to ~1.0 mmol/L lower total cholesterol than Class I obesity.
Why the study?
There is limited data on the associations between newer obesity indices such as VAI and BAI and lipid profile in obese non-diabetic patients.
Cross-Sectional (n=66)
No
Absolute Event Rate: 5% vs 6%
p-value: p=<0.05
Paradoxical lower cholesterol in Class III obesity warrants verification; leaves open visceral adiposity's role in dyslipidemia.
BACKGROUND: The aim of this cross-sectional study was to examine the relationship between obesity and lipid markers. MATERIAL AND METHODS: We divided 66 non-diabetic adult obese patients (mean age: 55.8±11.6 years) into 3 groups according to body mass index (BMI). All patients were measured for waist circumference (WC), hip circumference (HC), body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), body adiposity index (BAI), and visceral adiposity index (VAI). Serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) were determined, and lipid indices TC/HDL, LDL/HDL, and TG/HDL were also estimated. RESULTS: TC and LDL-C in Group III were lower than in Group I (5.0±1.0 vs. 6.0±1.0 mmol/L, and 2.9±0.9 vs. 3.8±1.2 mmol/L; p<0.05 for both). Negative correlations were found between: BMI and TC, LDL, and HDL (r=-0.291; r=-0.310, r=-0.240, respectively); and WC, WHR, VAI, and HDL (r=-0.371, r=-0.296, r=-0.376, respectively). Positive correlations were found between WC, WHR, and TG/HDL (r=0.279, r=0.244, respectively) and between VAI and: TC (r=0.327), TG (r=0.885), TC/HDL (r=0.618), LDL/HDL (r=0.480), and TG/HDL (r=0.927). CONCLUSIONS: Obesity is associated with lipid disturbances, especially with HDL-C reduction, in obese non-diabetic patients. VAI is strongly related to lipid profile and thus may be the most valuable obesity index in obese patients with dyslipidemias.
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Jacek Rysz (2014) conducted a cross-sectional in Obesity and Dyslipidemia (n=66). Class III obesity (BMI ≥40 kg/m2) vs. Class I obesity (BMI 30.0-34.9 kg/m2) was evaluated on Total cholesterol (TC) serum level (mmol/L) (p=<0.05). In non-diabetic obese patients, Class III obesity was paradoxically associated with lower total cholesterol than Class I obesity (5.0 vs. 6.0 mmol/L, p<0.05), while visceral adiposity index strongly correlated with lipid disturbances.
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