Key result
Epigenetic modifications interact with environmental factors to drive hypertension in older adults.
Why the study?
Essential hypertension in elderly individuals aged 75 years and older is common, but its multifactorial causes and epigenetic mechanisms remain incompletely understood.
May inform essential hypertension in elderly; leaves open need for validation before any practice implications.
The causes of high blood pressure are numerous and are based on the important distinction between the various types of arterial hypertension, which sees the existence of so-called essential hypertension and the so-called secondary hypertension. The elderly, considered as individuals 75 years of age and older, with essential hypertension, represent a conspicuous percentage of subjects suffering from diseases in the general population. Essential hypertension is the hypertensive state whose presence is imputed to a multiplicity of predisposing factors, since it is impossible to establish with certainty a precise and univocal triggering cause.
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Valerio Massimo Magro (2019) conducted a review in Essential hypertension. Epigenetic modifications, such as DNA methylation and histone alterations, interact with environmental factors to play a significant role in the genesis and maintenance of hypertension in the elderly.
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