All articles of this category Synthetic routes to natural products using isoxazole derivatives as key intermediates are reviewed. 1. Introduction 2. General Considerations 2.1. Methods of Preparation 2.2. Functionalization 2.3. Ring Opening Procedures 3. Synthesis of Natural Products via Isoxazole Intermediates 3.1. Isoxazoles as Masked New Heterocyclic Rings 3.2. Isoxazoles as Masked Aromatic Rings 3.3. Isoxazoles as Masked Fused Rings 3.4. Isoxazoles as Masked Aldol and Related Moieties 4. Conclusions
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Baraldi et al. (1987) studied this question.