Key result
ACE inhibitor plus CCB linked to ~3.4-fold higher odds of blood pressure control vs other regimens.
Why the study?
Despite guideline recommendations for combination antihypertensive therapy in stage 2 hypertension or high cardiovascular risk, real-world evidence on its effectiveness remains essential.
Does combination antihypertensive therapy, specifically ACE inhibitor plus calcium channel blocker, improve blood pressure control in adults with primary hypertension?
Cohort (n=150)
No
Does combination antihypertensive therapy, specifically ACE inhibitor plus calcium channel blocker, improve blood pressure control in adults with primary hypertension?
Odds Ratio: 3.42 (95% CI 1.54–7.61)
p-value: p=0.002
Combination antihypertensive therapy, particularly an ACE inhibitor plus a calcium channel blocker, is highly effective in achieving target blood pressure in real-world clinical practice.
ACEI plus CCB was associated with higher BP control odds; leaves open whether it should be preferred over other combinations in practice.
Background : Hypertension is one of the leading non- communicable diseases contributing to cardiovascular morbidity and mortality worldwide . Despite the availability of various antihypertensive agents , many patients fail to achieve recommended blood pressure targets . Current clinical guidelines recommend combination antihypertensive therapy for patients with stage 2 hypertension or high cardiovascular risk because it provides greater blood pressure reduction than monotherapy . However , real- world evidence regarding the effectiveness of combination therapy remains essential. Objective : To analyze the effectiveness of combination antihypertensive therapy in achieving blood pressure control among hypertensive patients. Methods : A retrospective cohort study was conducted using medical records of hypertensive patients receiving combination antihypertensive therapy between January and December 2025. A total of 150 patients were selected through consecutive sampling. Variables included patient characteristics , antihypertensive combination regimen , comorbidities , treatment duration , and blood pressure control . Data were analyzed using descriptive statistics , Chi- square tests , and multivariate logistics regression. Results : The most frequently prescribed regimen was ACE inhibitor plus calcium channel blocker (40.7%), followed by ARB plus calcium channel blocker (28.0%) and ACE inhibitor plus diuretic (21.3%). Overall , 72.0% of patients achieved target blood pressure . ACE inhibitor plus calcium channel blocker therapy was significantly associated with better blood pressure control (p<0.05). Longer treatment duration and medication adherence were also associated with successful blood pressure control. Conclusion : Combination antihypertensive therapy effectively improves blood pressure control among hypertensive patients . ACE inhibitor plus calcium channel blocker demonstrated superior effectiveness compared with other combination regimens.
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Eka Wisnu Kusuma (2026) conducted a cohort in Hypertension (n=150). ACE inhibitor plus Calcium Channel Blocker (CCB) vs. Other antihypertensive combination regimens was evaluated on Blood pressure control (<140/90 mmHg) (AOR 3.42, 95% CI 1.54-7.61, p=0.002). The combination of an ACE inhibitor and a calcium channel blocker significantly increased the odds of achieving blood pressure control (AOR 3.42) compared to other combination regimens among hypertensive patients.
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