Takotsubo Syndrome Triggered by Adrenaline Administration in Drug-Induced Anaphylaxis: A Case Report with a Review of The Literature

Background: Takotsubo syndrome (TTS) is a transient left ventricular dysfunction typically triggered by emotional or physical stress and associated with catecholamine excess.Case presentation: We report the case of a 45-year-old woman with a history of treated left breast cancer who presented to the emergency department with renal colic. Following antibiotic administration, she developed a severe allergic reaction with rash and laryngeal edema, requiring treatment with corticosteroids and adrenaline. Although allergic symptoms improved, she subsequently developed dyspnea and orthopnea. Clinical examination revealed signs of left-sided heart failure. Electrocardiogram showed sinus tachycardia without repolarization abnormalities. Transthoracic echocardiography demonstrated basal hyperkinesia with apical akinesia, consistent with Takotsubo syndrome. Biological findings were unremarkable.Conclusion: This case highlights adrenaline-induced Takotsubo syndrome as a rare but important complication in the management of anaphylaxis.