After THA or TKA, aspirin alone was noninferior to rivaroxaban then aspirin for symptomatic VTE at 90 d

“For patients who are not at a high risk for venous thromboembolism, such as patients who have never had a blood clot before or patients who do not have cancer, considering aspirin alone is very reasonable after [TKA or THA].”

“Aspirin is a commonly available and inexpensive oral medication with the potential to simplify post-surgical prophylaxis for providers and patients, and the results of our trial provide strong evidence for clinical decision making when considering an aspirin-alone strategy.”

“We now have evidence that an aspirin only strategy for prevention of blood clots after hip and knee replacements is safe and effective, and hopefully this study can better inform patients and health care providers when caring for patients after joint replacements.”