Why the study?
Rivaroxaban effectively prevents post-operative VTE after TKA and THA but may worsen bleeding risk, whereas cost-effective aspirin may also be effective.
Does aspirin prevent venous thromboembolism as effectively as rivaroxaban in patients following total knee or hip arthroplasty?
Population
Patients undergoing TKA and THA across five studies (2257 aspirin group, 2337 rivaroxaban group)
Comparison
Aspirin vs rivaroxaban
Design
Systematic review and meta-analysis
Authors
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Supports aspirin as equivalent to rivaroxaban for post-arthroplasty VTE prophylaxis; reinforces Level 1 evidence of comparable efficacy and safety.
Does aspirin prevent venous thromboembolism as effectively as rivaroxaban in patients following total knee or hip arthroplasty?
Aspirin appears to be as effective and safe as rivaroxaban for VTE prophylaxis following total hip or knee arthroplasty, though limited by study heterogeneity.
Xu et al. (2020) studied this question.
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