Key result
Poor sleep quality is linked to ~38% higher odds of acute coronary syndrome.
Why the study?
Sleep quality remains underexplored in relation to the risk of acute coronary syndrome despite its recognition as a modifiable cardiovascular health determinant.
Is poor sleep quality associated with an increased risk of acute coronary syndrome?
Case-Control (n=150)
No
Is poor sleep quality associated with an increased risk of acute coronary syndrome?
Odds Ratio: 1.38 (95% CI 1.01–1.89)
Absolute Event Rate: 69.3% vs 53.3%
p-value: p=0.04
Poor sleep quality and its components are significantly associated with an increased risk of acute coronary syndrome, reinforcing the importance of sleep assessment in cardiovascular risk evaluation.
May support sleep assessment in ACS risk evaluation; leaves open causality and requires prospective validation before practice change.
Background and Aims Acute Coronary Syndrome (ACS) remains a leading cause of morbidity and mortality worldwide. The World Health Organization estimates that cardiovascular diseases will account for 13.4% of global deaths by 2030. In Indonesia, coronary heart disease contributes to 26.4% of total mortality. Emerging evidence highlights sleep as a modifiable determinant of cardiovascular health, as emphasized in the Life’s Essential 8 framework by the American Heart Association. However, sleep quality remains underexplored in relation to ACS. This study aimed to evaluate the association between sleep quality and the risk of ACS. Methods This observational case-control study included 150 participants (75 hospitalized ACS patients and 75 outpatient clinic nurses from RSUDZA Banda Aceh as controls). Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Associations were analyzed using the Chi-square test. Results Poor sleep quality was more prevalent in ACS patients (69.3%) than controls (53.3%). A significant association was found between ACS and overall sleep quality (p = 0.04; OR 1.38; 95% CI 1.01–1.89). Significant associations were also observed for sleep efficiency (p < 0.001; OR 0.06), duration (p = 0.05; OR 0.50), latency (p < 0.001; OR 0.46), disturbances (p < 0.001; OR 13.2), sleep medication use (p = 0.002; OR 2.2), daytime dysfunction (p = 0.005; OR 2.52), and sleep satisfaction (p < 0.001; OR 0.33). Conclusion Sleep quality and its components are significantly associated with ACS risk, supporting the inclusion of sleep assessment in cardiovascular risk evaluation.
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Safita et al. (2026) conducted a case-control in Acute Coronary Syndrome (ACS) (n=150). Poor sleep quality vs. Good sleep quality / unexposed was evaluated on Acute Coronary Syndrome (OR 1.38, 95% CI 1.01-1.89, p=0.04). Poor sleep quality was significantly associated with an increased risk of acute coronary syndrome (OR 1.38; 95% CI 1.01-1.89; p=0.04).
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