Key result
CDH13 G allele linked to ~2 g/m²·⁷ lower LVMI, but effect lost in short sleepers.
Why the study?
The association of East Asian adiponectin-related genetic variants with left ventricular mass index and whether sleep duration modifies these genetic associations in youth had not been established.
Does habitual sleep duration modify the association between adiponectin-related genetic variants (such as CDH13 rs4783244) and left ventricular mass index in youths at risk for metabolic syndrome?
Cohort (n=559)
The following measurements were measured by a sonographer who was blinded to group
No
Does habitual sleep duration modify the association between adiponectin-related genetic variants (such as CDH13 rs4783244) and left ventricular mass index in youths at risk for metabolic syndrome?
Answers are grounded in this paper and cite their sources.
Carriers of the CDH13 rs4783244 G allele have lower left ventricular mass index in young adulthood, an effect independent of circulating adiponectin levels that is preserved with longer habitual sleep duration but lost with short sleep duration (≤7 hours/day).
Left ventricular mass index (LVMI) provides a metric for cardiovascular disease risk. We aimed to assess the association of adiponectin-related genetic variants resulting from GWAS in East Asians (loci in/near CDH13 , ADIPOQ , WDR11FGF, CMIP and PEPD ) with LVMI, and to examine whether sleep duration modified these genetic associations in youth. The 559 subjects aged 15–28 years were recruited from the Beijing Child and Adolescent Metabolic Syndrome study. Among the six loci, CDH13 rs4783244 was significantly correlated with adiponectin levels ( p = 8.07 × 10 −7 ). The adiponectin-rising allele in rs4783244 locus was significantly associated with decreased LVMI ( p = 6.99 × 10 −4 ) after adjusting for classical cardiovascular risk factors, and further for adiponectin levels, while no significant association was found between the other loci and LVMI. Moreover, we observed a significant interaction effect between rs4783244 and sleep duration ( p = .005) for LVMI; the genetic association was more evident in long sleep duration while lost in short sleep duration. Similar interaction was found in the subgroup analysis using longitudinal data ( p = .025 for interaction). In this young Chinese population, CDH13 rs4783244 represents a key locus for cardiac structure, and confers stronger cardio-protection in longer sleep duration when contrasted with short sleep duration.
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Li et al. (2018) conducted a cohort in Youths at risk of cardiovascular disease and metabolic syndrome (n=559). CDH13 rs4783244 adiponectin-raising G allele and habitual sleep duration vs. CDH13 rs4783244 T allele carriers and short sleep duration (<=7 h/day) was evaluated on Left ventricular mass index (LVMI, g/m^2.7) (beta = -1.978 g/m^2.7 per additional G allele, p=6.99 x 10^-4). The CDH13 rs4783244 G allele was associated with decreased LVMI and interacted with sleep duration, losing cardio-protection in short sleepers.
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