Key result
Elevated BNP, troponin, depression, and renal disease predict higher 1-year mortality in acute HF.
Why the study?
Clinical risk stratification of patients hospitalized with acute heart failure using BNP, TnI, and hsCRP biomarkers and co-morbidities to predict one-year mortality was investigated.
Cohort (n=124)
No
May support biomarker risk stratification in AHF; leaves open whether integration improves one-year outcomes.
Introduction/Objective. Clinical risk stratification of patients hospitalized due to acute heart failure (AHF) applying B-type natriuretic peptide (BNP), troponin I (TnI), and high-sensitivity C-reactive protein (hsCRP) biochemical markers can contribute to early diagnosis of AHF and lower mortality rates. The aim of this study was to investigate the prognostic significance of biomarkers (BNP, TnI, and hsCRP) and co-morbidities concerning one-year mortality in patients with AHF. Methods. Clinical group comprised 124 consecutive unselected patients, age 60?80 years, treated at the Coronary Care Unit of the Niska Banja Institute, Nis. The patients were monitored for one year after the discharge. During the first 24 hours after admission, BNP, TnI, and hsCRP were measured in fasting serum. Results. Total one-year mortality was 29.8%. The levels of serum BNP were significantly higher in the group of non-survivors compared to the group of survivors (1353.8 ?} 507.8 vs. 718.4 ?} 387.6 pg/mL, p < 0.001). We identified several clinical and biochemical prognostic risk factors by univariate and multivariate analysis. Independent predictors of one-year mortality were the following: BNP, TnI, depression, hypotension, chronic renal failure, ejection fraction, and right-ventricle systolic pressure. Conclusion. The presence of BNP and TnI biomarkers and several co-morbidities such as depression or chronic renal failure have significant influence on one-year mortality in patients with AHF.
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Petrović et al. (2017) conducted a cohort in Acute heart failure (n=124). Elevated biomarkers (BNP, TnI, hsCRP) and co-morbidities vs. Lower biomarker levels and absence of co-morbidities was evaluated on One-year mortality. In patients with acute heart failure, elevated BNP (1353.8 vs 718.4 pg/mL in non-survivors vs survivors; P<0.001), TnI, depression, and chronic renal failure independently predicted one-year mortality.
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