Key result
Elevated TRV over 2.55 m/s shows borderline link to prospective hospitalization in sickle cell anemia.
Cohort (n=243)
No
Hazard Ratio: 1.88 (95% CI 0.96–3.7)
p-value: p=0.07
Elevated tricuspid regurgitant velocity (TRV) measured by echocardiogram predicts death in adult sickle cell anemia (SCA)[1][1]–[4][2] and occurs in children,[5][3]–[9][4] although etiology and association with survival and complications requiring hospitalization are unknown. In children,
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Cox et al. (2014) conducted a cohort in Sickle cell anemia (n=243). Elevated tricuspid regurgitant jet velocity (TRV > 2.55 m/s) vs. TRV ≤ 2.55 m/s was evaluated on Hospitalization (HR 1.88, 95% CI 0.96-3.70, p=0.07). In Tanzanian children with sickle cell anemia, elevated tricuspid regurgitant jet velocity over 2.55 m/s was borderline associated with an increased risk of prospective hospitalization (HR 1.88).
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