Key Points• Eosinophil peroxidase (EPX) activity shows diagnostic resilience, reliably identifying eosinophilic chronic rhinosinusitis (eCRS) in real-world practice.• Swab EPX activity outperforms swab EPX protein as a measure of eCRS inflammation.• EPX activity reliably identifies eCRS compared with local and systemic cytokine measures. MethodsThis observational cohort study evaluated relationships between middle meatal swab-obtained EPX measures, ethmoid tissue and plasma cytokine levels, and disease severity in adult participantsChristian Caceres and Evan D. Marsh are equal contributors of this work.
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Caceres et al. (2026) studied this question.
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