Why the study?
The cardiac impact mechanisms of doxorubicin in early life chronic moderate protein deficiency malnutrition and potential mitigation strategies were unclear.
Does the intensive phase of chemotherapy alter serum cytokines and cognitive function in children?
Cohort (n=15)
Does the intensive phase of chemotherapy alter serum cytokines and cognitive function in children?
Intensive chemotherapy in pediatric patients is associated with significant reductions in serum IL-6 and TNF-α alongside selective working memory decline, though these phenomena are not statistically correlated.
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Patel et al. (2026) conducted a cohort in Leukemia (n=15). Intensive phase of chemotherapy vs. Baseline was evaluated on Change in Working Memory Index (MD -7.9, 95% CI -13.9 to -1.9, p=0.017).
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