Key result
The HLA-DRB1*01:03 allele may contribute to inflammatory bowel disease susceptibility by promoting a loss of tolerance to interleukin-10, leading to the generation of pathogenic autoantibodies.
The finding of a link between HLA-DRB1*01:03 and anti-IL-10 autoantibodies offers a mechanistic explanation for a strong genetic association in ulcerative colitis.
To the Editor: Gharahdaghi et al. (June 11 issue) 1 found a significant association between neutralizing anti–interleukin-10 autoantibodies and HLA-DRB1*01:03 in patients with inflammatory bowel disease (IBD). These findings may offer a mechanistic explanation for one of the strongest and most reproducible genetic associations in ulcerative colitis. 2 Indeed, the observation that most of the patients who were positive for anti–interleukin-10 autoantibodies carried HLA-DRB1*01:03 raises the possibility that this allele contributes to disease susceptibility by promoting a loss of tolerance to interleukin-10 that leads to the generation of pathogenic autoantibodies. 3 This model links genetic predisposition, adaptive immunity, and cytokine dysregulation within a . . .
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Küçük et al. (2026) conducted a letter in Inflammatory bowel disease. HLA-DRB1*01:03 allele was evaluated. The HLA-DRB1*01:03 allele may contribute to inflammatory bowel disease susceptibility by promoting a loss of tolerance to interleukin-10, leading to the generation of pathogenic autoantibodies.
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