Key result
Captopril renal scintigraphy detects clinically significant renal artery stenosis via asymmetric ACE-inhibition response.
Why the study?
There is a need for a safe, simple, reliable, cost-effective method to detect clinically significant renal artery stenoses in patients who may benefit from revascularization.
ACEI-based imaging may aid noninvasive RAS screening in refractory hypertension; leaves open optimal technique and revascularization benefit.
-As the population ages, renal artery stenosis has been increasingly detected among patients with refractory hypertension and/or renal dysfunction. There is a need for a safe, simple, reliable, cost-effective method for detecting clinically significant renal artery stenoses in patients who will benefit from revascularization. The asymmetric renal response to angiotensin converting enzyme inhibition in the setting of renal artery stenosis is the basis for several diagnostic techniques that screen patients with suspected renal artery stenoses to determine functional significance. Captopril renal scintigraphy is the most widely applied, however, ACE inhibition in conjunction with ultrasound and magnetic resonance are the focus of the most recent research. This review focuses primarily on the physiologic basis, indications, techniques and utility of captopril renal scintigraphy. Newer captopril imaging methods are introduced and consideration given to practical issues such as cost and risk/benefit analysis. KEYWORD Captopril - renal artery - radioisotope renography
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Collins et al. (2000) conducted a review in Renal artery stenosis. Captopril renal scintigraphy was evaluated. Captopril renal scintigraphy is a widely applied diagnostic technique for detecting clinically significant renal artery stenoses based on the asymmetric renal response to ACE inhibition.
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