Key result
Simplified captopril renography was 91% sensitive and 94% specific for diagnosing renal artery stenosis, and captopril-induced abnormalities strongly predicted blood pressure improvement (p=0.0004).
Why the study?
Does simplified captopril renography accurately diagnose renal artery stenosis and predict blood pressure response to revascularization in hypertensive patients?
Population
94 clinically selected hypertensive patients with a high clinical likelihood of renovascular hypertension…
Comparison
Simplified captopril renography protocol vs Renal angiography
Design
Cohort
Follow-up
3 months (for revascularization subgroup)
Authors
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Supports noninvasive RAS evaluation in hypertension but should not yet change practice; leaves open need for randomized outcome trials.
Cohort (n=94)
Does simplified captopril renography accurately diagnose renal artery stenosis and predict blood pressure response to revascularization in hypertensive patients?
Absolute Event Rate: 83.3% vs 18.8%
p-value: p=0.0004
Simplified captopril renography is highly sensitive and specific for diagnosing renal artery stenosis and accurately predicts blood pressure response to revascularization.
Setaro et al. (1991) conducted a cohort in Hypertension and suspected renal artery stenosis (n=94). Simplified captopril renography vs. Lack of captopril-induced changes was evaluated on Cure or improvement in blood pressure control following revascularization or nephrectomy (p=0.0004). Simplified captopril renography was 91% sensitive and 94% specific for diagnosing renal artery stenosis, and captopril-induced abnormalities strongly predicted blood pressure improvement (p=0.0004).
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