Key result
Sudden death accounts for ~12% of in-hospital schizophrenia fatalities, driven primarily by ischemic sudden cardiac death.
Why the study?
Sudden cardiac death in patients with schizophrenia and its association with chronic ischemic heart disease, neuroleptic cardiomyopathy, metabolic disturbances, and antipsychotic cardiotoxicity was not well characterized.
Observational
No
Supports cardiac monitoring for schizophrenia inpatients on antipsychotics; leaves open applicability to contemporary regimens.
Under the special scheme materials of archive of the Tver regional psychiatric clinical hospital with 1952 for 2010 are studied and statistically analysed. Sudden death is ascertained at 12.4 % died in-patient of schizophrenia without dependence from their sex and age. In the suppressing majority it is sudden cardiac death owing to a chronic ischemic heart disease and an neuroleptic cardiomyopathy. The part of cases is caused by exchange infringements at schizophrenia (attrition or adiposity). The sudden cardiac death among suffering by schizophrenia is connected to some extent with side cardiotoxic effect of various antipsychotic drugs, both classical, and atypical.
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Volkov VP (2019) conducted an observational in Schizophrenia. Schizophrenia and antipsychotic drug use was evaluated on Sudden death. Sudden death accounted for 12.4% of mortalities among hospitalized schizophrenia patients, predominantly presenting as sudden cardiac death linked to ischemic heart disease and antipsychotic use.
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