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A practical procedure for mouse hypophysectomy by the parapharyngeal approach has been developed. Innovations include tracheal cannulation, resuscitation in an 02 atmosphere, and hydrocortisone therapy. Mice of the A/He strain are particularly vulnerable to the effects of pituitary loss and will survive only if they are supplied with an adrenal steroid at regular intervals. On the other hand, mice of the C57BL, C3H, BALB/c and Swiss albino strains do not require special postoperative handling.
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Lostroh et al. (1955) studied this question.
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