Key result
AVR improves symptom-free and overall survival in calcific aortic valve stenosis.
Why the study?
Calcific aortic valve stenosis is the most frequent structural heart disease with increasing mortality rates in Europe since 2000, and symptom onset indicates poor prognosis despite treatment options.
AVR improves prognosis once symptoms emerge; leaves open optimal timing and medical options in asymptomatic AS.
C alcific aortic valve stenosis (aortic stenosis[AS] characterised by progressive fibrocalcific leaflet remodelling) leading to blood flow restriction is the most frequent structural heart disease, with mortality rates increasing across Europe since 2000.Symptoms are insidious at onset and development of any of the three cardinal symptoms of angina, syncope, or heart failure portend a poor prognosis, with aortic valve replacement (AVR) showing a consistent improvement for both symptom-free and overall survival.
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Rahman et al. (2023) conducted an editorial in Calcific aortic valve stenosis. Aortic valve replacement (AVR) was evaluated. Aortic valve replacement (AVR) consistently improves symptom-free and overall survival in patients with calcific aortic valve stenosis.
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