Key result
T2D is linked to ~10.4-fold higher odds of metabolic syndrome compared with normal glucose tolerance.
Why the study?
Metabolic syndrome is a major risk factor for cardiovascular disease, and this study investigated how its prevalence varies by glucose homeostasis across different age and gender groups in Chinese subjects.
Does impaired glucose homeostasis (IFG/IGT and T2D) increase the prevalence of metabolic syndrome compared with normal glucose tolerance in Chinese subjects across different age and gender groups?
Cross-Sectional (n=9,257)
Yes
Does impaired glucose homeostasis (IFG/IGT and T2D) increase the prevalence of metabolic syndrome compared with normal glucose tolerance in Chinese subjects across different age and gender groups?
Answers are grounded in this paper and cite their sources.
Metabolic syndrome prevalence in Chinese adults rises sharply from 21.7% in normal glucose tolerance to 62.7% in prediabetes (IFG/IGT) and 74.3% in type 2 diabetes, with peak relative odds in 30-to-39-year-olds supporting cardiometabolic screening and intervention by age 30.
BACKGROUND: Metabolic Syndrome (MetS) is a high risk factor for Cardiovascular Diseases (CVD). We estimated to investigate how MetS prevalence by glucose homeostasis varies across different age and gender groups. METHODS: We studied 9257 Chinese subjects over the age of 15 years in two cross-sectional surveys in 2006. With oral glucose tolerance test (OGTT) test, 2341 subjects were normal glucose tolerance (NGT), and 5448 were diagnosed as having type 2 diabetes (T2D). All other 1468 subjects were considered to be impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) subjects. Diabetes was diagnosis by WHO99 criteria. We used modified NCEP-III criteria for the diagnosis of MetS. RESULTS: The prevalences of MetS in the male NGT, IFG/IGT and T2D groups were 25.9% (404/1559), 65.6% (769/1172), and 73.5% (2483/3376), respectively. The prevalences of MetS in the female NGT, IFG/IGT and T2D groups were 13.4% (105/782), 51.0% (151/296), and 75.4% (1563/2072), respectively. The prevalence of MetS in the male IFG/IGT group gradually decreased from 73.26% to 41.08% in subjects over the age of 30 years. The prevalence of MetS in the female IFG/IGT group gradually increased from 30% to 75% with aging. CONCLUSIONS: The prevalence of MetS in subjects with different glucose tolerances in China was high and gradually increased with impaired glucose homeostasis both in males and females.
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Xiang et al. (2012) conducted a cross-sectional in Impaired glucose homeostasis (IFG/IGT and Type 2 Diabetes) and Metabolic Syndrome (n=9,257). Type 2 Diabetes (T2D) and IFG/IGT (impaired glucose homeostasis) vs. Normal Glucose Tolerance (NGT) was evaluated on Prevalence of Metabolic Syndrome (MetS) diagnosed by modified NCEP-ATPIII criteria (OR 10.435, 95% CI 9.297-11.711, p=<0.001). Impaired glucose homeostasis markedly increased metabolic syndrome prevalence in Chinese subjects from 21.7% in NGT to 62.7% in IFG/IGT (OR 6.078) and 74.3% in T2D (OR 10.435, 95% CI 9.297-11.711).
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