Comparison of the Outcome of Altplas Administration after Acute Ischemic Stroke in Patients Over 80 Years and Under 80 Years Admitted

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Acute Ischemic Stroke (n=51). Intervention: Age over 80 years treated with Alteplase vs. Age under 80 years treated with Alteplase. Primary outcome: Improvement based on NIHSS score at discharge (p=0.534).

Q: What does this research mean for the field?

Alteplase administration in acute ischemic stroke patients over 80 years old achieves rates of neurological improvement comparable to those in patients under 80 years old. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Sepideh Karkon; Hasan Aliashrafzadeh; Fariborz Rezayitalab; Mohammadreza Sobhani; Mahdi Zarei

doi:10.47750/pnr.2022.13.s03.105

January 1, 2022Journal of Pharmaceutical Negative ResultsOpen Access

Comparison of the Outcome of Altplas Administration after Acute Ischemic Stroke in Patients Over 80 Years and Under 80 Years Admitted

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Why the study?

Few studies have compared the effectiveness of alteplase in patients over 80 years old versus under 80 years old after acute ischemic stroke, and reliable evidence is lacking.

Study Design

Type

Cross-Sectional (n=51)

Multicenter

No

PICO

P

Population

51 patients with acute ischemic stroke treated with rtPA within 4.5 hours of symptom onset, evaluated across two age groups (over 80 and under 80 years old) with up to 6 months of follow-up.

E

Exposure / Comparator

Age over 80 years treated with Alteplase vs Age under 80 years treated with Alteplase (0.9 mg/kg)

O

Primary Outcome

Improvement based on NIHSS score at discharge, p=0.534

Main Result

Absolute Event Rate: 62.5% vs 71.42%

p-value: p=0.534

Limitations

Single-center study with population-specific results which may not be extrapolated to other communities
Some variables may be affected by confounding factors and demographic conditions

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Cite This Study

Karkon et al. (2022) conducted a cross-sectional in Acute Ischemic Stroke (n=51). Age over 80 years treated with Alteplase vs. Age under 80 years treated with Alteplase was evaluated on Improvement based on NIHSS score at discharge (p=0.534).

synapsesocial.com/papers/6ac9b748b6ab1a3d69cfe843 https://doi.org/10.47750/pnr.2022.13.s03.105

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Comparison of the Outcome of Altplas Administration after Acute Ischemic Stroke in Patients Over 80 Years and Under 80 Years Admitted

Study Design

PICO

Main Result

Limitations

Ask about this paper

Abstract

Discussion

Cite This Study

Comparison of the Outcome of Altplas Administration after Acute Ischemic Stroke in Patients Over 80 Years and Under 80 Years Admitted

Study Design

PICO

Main Result

Limitations

Ask about this paper

Abstract

Discussion

Cite This Study

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